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Enrichment of studies with patients with a higher severity of illness would increase ACM. Data on symptom resolution in nonventilated HABP support development of a patient reported outcome instrument. At the request of the US Food and Drug Administration FDA, the Foundation for the National Institutes of Health FNIH Biomarkers Consortium established a project team to advance scientifically rigorous hospital acquired bacterial pneumonia HABP/ventilator associated bacterial pneumonia VABP drug development based on a noninferiority NI study design . The multidisciplinary team of representatives from government, academia, and industry with expertise in antibiotic development submitted preliminary recommendations to the FDA docket . All cause mortality ACM was acknowledged as an objective, verifiable, and reproducible endpoint, especially for VABP. The team supported utilizing the intention to treat ITT population as the primary efficacy set, with the microbiological ITT population as a key secondary subset.



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Our work aims to prepare kids for any reading and writing task they will face or set themselves, to turn them into life long, confident readers and writers who display agency and independence in their future endeavors. That is, our aims reach beyond state testing and fulfillment of tasks for schools. We aim to strengthen a generation of readers and writers. To achieve these goals, the Reading and Writing Project supports teachers, administrators, and school change agents with professional development, curriculum, and instructional methods. The work of the Reading and Writing Project is informed by research in all of these areas as well as the more specialized categories of literacy. TCRWP reading instruction relies on research that shows that kids need to read a lot of texts, with high comprehension, in order to move up levels of text complexity.



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Earlier experiments had suggested that the amygdala, a pair of almond sized bundles of nerve fibers in the middle of the brain, is activated when people are anxious. Etkin and his colleagues, though, believed the amygdala was only one part of the process. They wanted to document in greater detail how the brain regulates without any conscious awareness the emotional conflict underlying anxiety. In a nutshell, he wanted to answer this question: What is different in the brains of people who can implicitly regulate their feelings of anxiety as compared with those who cannot?Etkin was looking for a task that would elicit the unconscious brain response to emotional conflict, and the solution arose as he was riding a bus across Manhattan to meet his wife. On the seat next to him was a colleague, Tobias Egner, PhD, who had been looking at means of testing in fMRI studies how the brain deals implicitly with cognitive not emotional conflicts. Egner, now an assistant professor in the psychology department at Duke University, told him of a classic technique for studying non emotional conflict the Stroop task first identified in Germany in the late 1920s and later made public in the United States by the psychologist John Ridley Stroop.

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